We wish our continuing effort can make IntPath one of the most useful databases in pathway studies that can benefit a variety of related researches.
Rather, the technology is most useful in drawing attention to pathways, and sometimes individual genes, that are most relevant to the recent in vivo experience of the cell population being studied.
For these reasons, predicting responsiveness to a given TBA or other emerging biotherapies (such as inhibitors of the interleukin-1 or interleukin-6 pathways) would be most useful.
In order to connect the understanding of the dynamics of HABs and pathogen populations and the ecosystem within which they live to the effects on human health, it is probably most useful to work backwards along the pathway indicated in Figure 1.
Furthermore, the technique described here is most useful in clustering specific genes involved in pathways when meta-analysis hits from known interacting proteins can be overlapped.
The approach is most useful in informing clinical decisions where the optimal pathway is not immediately apparent, and for making clinical reasoning explicit [ 28].
As human behaviours are often not faithfully modelled in animal systems (Nestler and Hyman, 2010; O'Leary and Cryan, 2013), whole-animal analyses might be most useful when they focus on specific molecular and cellular pathways that underlie a pathology.
Thus, this platform will allow for an assessment of assay coverage across the approximately 1,100 human pathways and where new assays might be most useful.
Drosophila pink1 (dpinknockoutkout flies have thus far been the most useful for assessing PINK1 function perhaps because of the autosomal recessive nature of PINK1 mutations and compensatory pathways in vertebrates.
One of the most useful analyses in terms of understanding the biology of the network is the identification of disease pathways by locating subnetworks or modules within the overall network (57– 61).
