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The ability to predict pCR, arguably the most useful endpoint of all, could not be assessed in this cohort, because no patient achieved a pCR.
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The PRO measures must also have evidence documenting responsiveness or sensitivity to changes in clinical status to be most useful as effectiveness endpoints in clinical trials.
The measures must also have evidence documenting responsiveness and interpretation guidelines (i.e., minimal important difference) to be most useful as effectiveness endpoints in clinical trials.
We suggest that reporting a range of outcomes in this way is useful for extrapolation to a variety of different settings; that is, a more relaxed endpoint definition may be most useful in calculating likely vaccine efficacy in field settings, whereas strict criteria may be more applicable to the development of novel diagnostic assays.
Despite these challenges, properly designed clinical trials with validated endpoints will yield the most useful information on the neuroprotective effects of therapy, and may provide new treatment options to prevent the loss of neurologic function, including vision.
Clinical cure was the most frequently used endpoint but its definition was highly variable.
Most useful?
These will be most useful".
Most useful website?
The Chechens' most useful weapon?
The most useful is the abrasive disk.
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