Sentence examples for most upstream target from inspiring English sources

To further examine this question, we estimated the role of exogenous insulin by correlating insulin infusion dose at the time of the biopsy with Akt phosphorylated at T308, our most upstream target.

The identification of CHEK1 expression as high in lymphomas and leukemias, including AML, prompted Morgado-Palacin et al. to investigate targeting ATR and ATM, the most upstream kinases in the DNA damage response, as possible AML therapies.

Targeting DNA-PKcs, however, would exploit the most upstream component of the DNA-PK-JNK axis.

It was also reported that miRNAs predominantly target positive regulatory motifs, highly connected scaffolds and most downstream network components such as signaling transcription factors, but less frequently target negative regulatory motifs, common components of basic cellular machines and most upstream network components such as ligands [ 32].

However, in spite of the detailed information available on the downstream targets of nutrient regulation of ribosomal RNA and protein expression, the most upstream mechanisms involved in the actual sensing of the nutrients largely remain unclear.

To identify genes at the core of the tumor suppressor program, we decided to focus on direct transcriptional targets of TGF-β, reasoning that hierarchically these would be the most upstream regulators of the program.

In all cases the most upstream TSS was used for each gene.

This compound might interfere with cell migration by modulating the activity of different upstream target kinases.

Lake Mendocino is the most upstream reservoir located on the East Fork of the Russian River.

So what is the most upstream regulator?

The pharmacological upstream target of RGE remains to be confirmed.