Sentence examples for most upstream protein from inspiring English sources

The protein GacGacA has no state-change rule because it is the most upstream protein and none of the other proteins in the model act upon it and no other proteins are known to regulate it in P. syringae, though HrpXY is known to regulate GacSGacA in Erwinia and Pantoea stewartii.

Previous reports propose that Atg17 and its proposed functional counterpart RB1CC1 acts most upstream of all Atg/ATG proteins in yeast and mammals, respectively., Our genetic epistasis results also support the upstream role of Atg17 in autophagy in Drosophila.

However, in spite of the detailed information available on the downstream targets of nutrient regulation of ribosomal RNA and protein expression, the most upstream mechanisms involved in the actual sensing of the nutrients largely remain unclear.

The Atg1 kinase complex, and its subunit Atg17 in yeast and the corresponding proposed ortholog RB1CC1 in mammalian cells in particular, is suggested to act most upstream in the hierarchy of Atg protein complexes., In line with that, we found that knockdown of Atg17 prevented starvation-induced punctate mCherry-Atg1 localization (Fig. 2H and N).

To characterize the signal transduction pathway responsible for the attenuation of protein synthesis by TRAP1, we focused on the eIF2 α upstream protein kinases involved in the most common stress adaptive responses of cancer cells.

The most upstream site contains a binding site for CTCF, a known insulator protein, while the other sites are predicted to associate with the nuclear matrix.

Either way, a bZIP-type transcription factor appears to be the most upstream component that is regulated at the transcriptional level by an ROS-activated Myb protein (pathway-1 in Figure 8).

Lake Mendocino is the most upstream reservoir located on the East Fork of the Russian River.

So what is the most upstream regulator?

This factor could be an associated protein or phosphorylation by upstream protein kinases.

Although proposed [43], we could not identify a solution with Bub3 as the most upstream factor.