Sentence examples for most upstream event from inspiring English sources

To simplify interpretation, we focused on the most upstream event in the insulin signaling cascade: IR autophosphorylation.

Along the central dogma, a causal mutation at the genetic level is unambiguously the most upstream event.

The most upstream event that can be identified until now is the switch between two viral promoters, the Q promoter (Qp) and the C promoter (Cp), which in turn determines expression of key regulatory viral proteins.

The most upstream event during PINK1/Parkin-mediated quality control of mitochondria is the discrimination of damaged mitochondria from their healthy counterparts by PINK1 via quantitative and qualitative regulation.

Our understanding of the mechanism of the licensing complex is limited; however, it is clear that its recruitment to centromeres following anaphase is the most upstream event known for CENP-A deposition.

In contrast, the fact that relative body condition (Kn) was lower in eels from the most upstream group in comparison to those sampled downstream could imply that passage of water barriers is an energetically and metabolically requiring event [ 35].

Lake Mendocino is the most upstream reservoir located on the East Fork of the Russian River.

So what is the most upstream regulator?

This suggests that the drug-induced loss of PcG repression is caused by an upstream event.

Interestingly, this effect persists for other downstream alternative TSS events (Additional file 1: Figure S14), indicating that intragenic enhancers can activate internal TSSs, but also affect transcription of the most upstream TSS to some extent.

Surprisingly, they can also affect the most upstream TSS.