Sentence examples for most upstream element from inspiring English sources

Of these, γH2AX is the most upstream element, sequentially followed in the cascade by conjugated ubiquitin, BRCA1, and Rad51.

For this analysis, pathway position was defined as the number of steps required to transduce the signal from the most upstream element (Grb2, position 0), to each of the pathway components (with proteins RSK1 3 sharing position 6, the most downstream position of the core pathway; Figure 2A; Additional file 1: Table S5).

They demonstrated that hyperactive forms of Msb2p and Hkr1p can activate the HOG pathway only in the presence of Sho1p, whereas a hyperactive Sho1p mutant activates the HOG pathway in the absence of both Msb2p and Hkr1p, indicating that Msb2p and Hkr1p are the most upstream elements in the Sho1p branch [ 47].

Our experiments demonstrate that iRhom is a new type of regulator of EGFR activity the most upstream control element in the pathway yet discovered.

Interestingly, the motifs identified in the intronic PCSs contain G+C and CpG more frequently than the elements identified in the most upstream transcriptional start sites.

In all cases the most upstream TSS was used for each gene.

So what is the most upstream regulator?

Specifically, a near upstream element AAUAAU sequence is located 11 nucleotides upstream of a potential cleavage site CA. Approximately 50 nt upstream of the potential cleavage site is a potential far upstream element that is U-rich.

BES1 can associate with upstream elements of most cellulose synthase genes and positively regulates cell wall synthesis [ 23].

However, the most significant link was to the 'transsulfuration pathway' and some of its upstream elements.

Previous studies identified that far upstream element-binding protein 1 (FBP1), a transcriptional regulator of c-Myc that is one of the most frequently aberrantly expressed oncogenes in various human cancers, including NPC, is an important biomarker for many cancers.