Sentence examples for most upstream components from inspiring English sources

Since FGF signaling can lead to the activation of multiple downstream effectors, each of which can participate in other signaling pathways, efforts to specifically control the FGF pathway have necessarily focused on the most upstream components.

Although they are chromosomally located in S. japonicum UT26, most upstream components of the lin pathway are found in unique regions of the UT26 genome associated with the insertion sequence IS 6100, suggesting that they have been acquired through horizontal transfer (Lal et al. 2006; Nagata et al. 2011).

Note that Bub1, the most upstream component in this example, is activated by some undefined external factor.

ft has been suggested to be the most upstream component of the Hpo pathway identified so far [17], [18], [19].

Consistent with previous reports [38], [41], we found that Bub1 is the most upstream component on the kinetochore.

Targeting DNA-PKcs, however, would exploit the most upstream component of the DNA-PK-JNK axis.

The complex is the most upstream component so far characterised of the environmental arm of the general stress response in B. subtilis[ 1, 4].

The GmERD15 (Glyma.14G055200) TF is the most upstream component characterized, and it is induced by osmotic and ER stress to trigger the expression of NRP/DCD genes.

However, the most upstream component of this regulatory pathway, BRMS1, apparently has dual roles that make its activities difficult to interpret.

Thus, CENP-A loading is inversely timed relative to mitotic CDK activity and KNL-2 seems to be the most upstream component of the centromere epigenetic regulation pathway (Fig.  3a).

In worm embryos, SPD-2 is the most upstream component of this module, and it is also essential for pericentriolar material (PCM) recruitment to the centrioles [1, 4, 15, 16].