Sentence examples for most upstream component from inspiring English sources

Note that Bub1, the most upstream component in this example, is activated by some undefined external factor.

ft has been suggested to be the most upstream component of the Hpo pathway identified so far [17], [18], [19].

Consistent with previous reports [38], [41], we found that Bub1 is the most upstream component on the kinetochore.

Targeting DNA-PKcs, however, would exploit the most upstream component of the DNA-PK-JNK axis.

The complex is the most upstream component so far characterised of the environmental arm of the general stress response in B. subtilis[ 1, 4].

The GmERD15 (Glyma.14G055200) TF is the most upstream component characterized, and it is induced by osmotic and ER stress to trigger the expression of NRP/DCD genes.

Since FGF signaling can lead to the activation of multiple downstream effectors, each of which can participate in other signaling pathways, efforts to specifically control the FGF pathway have necessarily focused on the most upstream components.

Although they are chromosomally located in S. japonicum UT26, most upstream components of the lin pathway are found in unique regions of the UT26 genome associated with the insertion sequence IS 6100, suggesting that they have been acquired through horizontal transfer (Lal et al. 2006; Nagata et al. 2011).

For this analysis, pathway position was defined as the number of steps required to transduce the signal from the most upstream element (Grb2, position 0), to each of the pathway components (with proteins RSK1 3 sharing position 6, the most downstream position of the core pathway; Figure 2A; Additional file 1: Table S5).

Although the Ulk1/2-Atg13-FIP200 complex is regarded as the major and most upstream factor in starvation induced autophagy, there is a growing body of evidence that autophagy can be induced even in the absence of some of its components.

Interestingly, the most upstream checkpoint component, Mps1, is ubiquitinated by the APC– Cdc20 at anaphase onset, leading to its degradation (Palframan et al. 2006).