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Experiments performed with alleles of the WS ecotype of both mutants, at only one time-point post-IR and with a different microarray procedure, indicated the same transcriptional trend at least for the most upregulated transcript, AtBRCA1.
We recently identified fibulin-1-mRNA as the most upregulated transcript in non-atherosclerotic arterial tissue from patients with type 2 diabetes.
Notably, the most upregulated transcript corresponded to a predicted H2O2-producing alcohol oxidase (1368318; CAZY family AA3_3).
Insulin growth factor 2 (IGF-2) is the single most upregulated transcript in as many as 80 90% of ACC cases.
In this cluster, the most upregulated transcript from early to mid-level interaction represents a polycistronic mRNA encoding the proteins RepA, Tap, and RepA3 that are required for plasmid replication.
The most upregulated transcript in the group of genes responding to oxidative stress was that encoding a cytosolic copper/zinc superoxide dismutase (CSD1), which was expressed at a 73-fold higher level in symptomatic plants compared with the control.
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NMD-inhibition experiments have shown that mutant TGFBR2 is one of the most upregulated transcripts, with 10-fold increased mRNA expression in one study[27], [37].
Inspection of the reported expression patterns of the most upregulated transcripts confirmed that CHI treatment significantly induced genes representative of PS-derived lineages and Wnt-related transcripts (supplementary material Table S1).
NGAL, also known as lcn2, is one of the most upregulated transcripts in the early postischemic mouse kidney and this finding has been confirmed in several other transcriptome profiling studies.
The most upregulated transcripts in goiters and hyperplastic lesions vs TN samples include genes as cytochrome c oxidase assembly protein COX15 homolog (COX15), dyskeratosis congenita 1, dyskerin (DKC1), and DnaJ (Hsp40) homolog, subfamily A, member 2 (DNAJA2).
Cystatin F was identified as one of the most upregulated transcripts in monocyte-derived dendritic cells undergoing LPS-induced maturation (Hashimoto et al, 2000) and was independently identified as CMAP (cystatin-like metastasis associated protein) whose level of expression correlated with metastatic potential in liver tumours (Morita et al, 1999).
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