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The latter gene was the most upregulated one in both types of PCLS (above 20 fold; Fig. 3c).
The most significantly downregulated microRNAs in BRAFwt compared to BRAFmut PTCs was mir492 and the most upregulated one was mir32.
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RankProd uses non-parametric rank product method to detect genes that are consistently found among the most strongly upregulated ones and the most strongly downregulated ones in a number of replicate experiments, comparing two different condition [ 18].
Another group found miR-199a, miR-214, and miR-200a as the ones most upregulated and miR-100 as the most downregulated miRNA in high-grade and late-stage ovary cancers [ 97].
miR-182 was one of the most upregulated DEMs in the T vs N contrast.
Using microarrays, we found that miR-183 was one of the most upregulated genes.
MiR-183 was one of the most upregulated miRNAs in ESCC tissues.
GADD45G was observed to be one of the most upregulated genes after SIRT1 activator treatment.
PCR array data demonstrated that GADD45G is one of the most upregulated genes after SIRT1 activator treatment.
We identified 51 upregulated miRNAs and 17 downregulated miRNAs in our array, and miR-183 was one of the most upregulated miRNAs.
In humans, PADI2 is one of the most upregulated genes in luminal breast cancer cell lines compared to basal lines [ 13, 14].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com