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We found that V1 was the most upregulated isoform with a 1.7-fold increase.
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Although we can not exclude the possibility that increased ALDH activity following MTA treatment (Supplementary Figure S3A) might also be contributed by other ALDH isoforms, ALDH1A2 is, however, one of the most upregulated genes associated with chemoresistance.
Only the top 50 (25 most upregulated and 25 most downregulated) were selected at this stage.
Complex I was the most upregulated complex and not stoichiometrically associated to the other complexes.
Among all 22,214 genes examined, CD177 mRNA was the most upregulated following endotoxin exposure.
IL-1β and IL-8 were the most upregulated genes and to a lesser extent TNF-α.
We recently identified fibulin-1-mRNA as the most upregulated transcript in non-atherosclerotic arterial tissue from patients with type 2 diabetes.
The most upregulated biological process (P) term was protein biosynthesis.
Applying GO, cell communication was the most upregulated biological process (P), enzyme regulator activity the most upregulated molecular function (F), and intrinsic to membrane the most upregulated cellular component (Table S7).
Using GO, ribonucleoprotein complex and ribosome were the most upregulated cellular components (C), and structural constituent of ribosome was the most upregulated molecular function (F) term.
Most upregulated genes (clusters 12 16) have an mRNA stabilization that cooperates with a TR increase.
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