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SAGE (serial analysis of gene expression) demonstrated that, of differentially upregulated mRNAs, CLDN3 and CLDN4 were among the six most upregulated in primary ovarian carcinoma cells [ 16].
The involvement of the most upregulated in VMR-CM cytokine RANTES has been reported in the progression of different tumor types, particularly in breast cancer [26], [36], [37].
Because of this, we performed further analysis to identify the genes that were most upregulated in END2 cells as compared to PYS2 and XEN cell lines (Table S1, END2 cells and Table S2, XEN cells).
A gene encoding Aux/IAA (IAA9 - Ciclev10025873m) was the most upregulated in our analysis.
Among significantly regulated miRNAs, miR-210 was most upregulated in CTGF-treated OASFs compared with controls.
Among these, CXCL2 expression was the most upregulated in Ad- Epas1-infected chondrocytes.
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Only 18 of the 50 most upregulated genes in normal ZG were also upregulated (fold change>2) in APAs when using ZF as the comparator tissue.
IM4 is the second most upregulated gene in parkin mutants [ 34], IM10 is upregulated in flies with neurodegeneration caused by mutated human tau[ 25], and Ect3 is the homolog of GLB1, a human gene associated with mental retardation [ 51].
In this paper, we report that CBX2 was consistently the most upregulated EpR in NEPC compared to PCa in our analyzed datasets.
Among these genes, IL8 was upregulated approximately 11-fold and was the most upregulated gene in MCF10A-HER2/HER3 MCF10A-HER2/HER3o all other cellstions (Table S1 in Additional file 1).
S100A4, a third member of the S100 family, was also one of the most upregulated genes in ependymoma with a difference in tag count of 6.6.
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