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Given the survival curves derived from the present analysis, the 2 better prognostic groups in the 3-tiered systems in principle qualify for surgery or radiosurgery, while such treatment might not be justified for many if not most of the patients in the most unfavourable group.
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The advantage of the SIR compared to RPA is that the tail of long-term survivors in the most unfavourable prognostic group is eliminated.
Even though the probability to observe this result was very low, patients in the low compliance profile group reported the most unfavourable score compared with the moderate and high compliance profile groups for five of the six EDSQ dimensions.
If one doesn't want to withheld potentially useful treatment, the group with the most unfavourable prognosis should be kept small.
In a four-year follow-up, a comparison between three groups from a working population showed that the group with combined burnout/fatigue problems had the most unfavourable course in terms of persistence of symptoms and absenteeism compared to individuals who reported only burnout or fatigue.
In our material, the combination of Cdc20 and securin expression resulted in an impressive survival difference between the groups of most favourable and most unfavourable prognosis.
Interestingly, combining the data also improved the prediction of outcome: ER α/GPER double positive was the most favourable group, whereas ER α/GPER double negative was most unfavourable (P<0.001, Figure 3B).
Black immigrants is in fact the least crime-prone group, which is very interesting if we consider that this also the group, particularly those coming from Africa, that faces the most unfavourable socio-economic conditions (see, for example, Algan et al. 2010).
Under the most unfavourable circumstances I think it will take about two years," he said.
Under the most unfavourable circumstances, I think it will take about two years".
And it has been introduced in the most unfavourable circumstances imaginable: in an atmosphere of confusion and bitterness.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com