First, a Naïve Bayes estimator is used to rank features from which the top-ranked will most likely contain the most informative features for prediction of the underlying biological classes.
However, due to the noisy nature of transcriptomic data and the large number of features compared to the sample size, most of the differences found in the networks inferred independently may not be linked with underlying biological processes.
In this context, different global parameters are commonly used to describe the properties of the whole network: centralities are indexes that permit the identification of the most important actors by characterizing the nodes that, more than others, are good candidates as regulators of the underlying biological process.
We find that the rank-based network significantly differs from the value-based network in several important aspects, and we argue that the former is able to better capture the global topology of the underlying biological system, including both strongly and weakly co-expressed modules, while the latter is dominated by the most strongly co-expressed modules.
The comparison shows that the detected pathways are different among most of the four profiles in many cases (the exception is cooperation and redundancy, see below), which might reflect the various underlying biological processes of complex diseases, e.g., in some conditions the genes compete to influence phenotype; in others, cooperation might drive dysregulation.
Findings could determine the underlying biological mechanism responsible for the vaccine's failure.
Now they are using the tools to find the underlying biological mechanisms that lead people to act, or not act, according to an economic theory.
It said marriage acknowledged "an underlying biological complementarity which, for many, includes the possibility of procreation".
Further research examining the underlying biological and cellular mechanisms of depression is warranted.
There are several models that have been proposed to explain the underlying biological, physiological, and/or psychological mechanisms of OT.
