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In most of these 18 datasets, samples were classified into two groups, one comprising of most normal samples and another for most tumor samples, based on our 187 gene signature (Figure S3).
Most tumor samples were positive for at least 6 markers.
Most tumor samples showed a membranous staining with varying intensity.
Most tumor samples were obtained from paraffin-embedded blocks made on initial diagnosis.
In similar fashion, most tumor samples clustered together, demonstrating common genetic features between the tumor specimens.
Hepsin was found to be overexpressed in most tumor samples, and validated by immunohistochemical analysis [ 14].
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Most (72/80) tumor samples harbored significant methylation changes at at least one locus.
Most clinical tumor samples are a mixture of normal and tumor cells at varying percentages, as well as genetically dissimilar subclones of cancer cells.
Our LIMMA analysis of the most recent tumor samples within the reference dataset identified more differentially expressed genes, an observation that seems to correlate well with the findings of Roepman et al. [ 3].
Most of the tumor samples were about 0.5 cm in diameter.
HAX-1 up-regulation was detected in most of the tumor samples (Table 4, Fig 7A and 7B).
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