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Exact(5)
Since sensitivity measures the inclusion of true positives in the estimate, as more stringent filters are applied, the sensitivity suffers: filters only remove publications from the raw result returned by the search engine, so raw results will contain the most true positives.
The prediction of functional regulatory elements by PSSMs, although having good sensitivity (most true positives are found), suffers from poor specificity (many false positives are predicted) [ 53].
A ROC5 of 0.5 denotes mixed ranks, and a score close to one represents results with most true positives followed by false positives.
The trained SNVMix1 model had the most true positives of all models; however, the F-measure and MCC were lower than JointSNVMix1.
For any number of false positives (i.e. at any error rate), the profile-sequence searches against the databases of full consensus sequences yielded most true positives (Fig 2; top three curves: MET-full, MF-full, MR-full).
Similar(55)
We tested different cut offs for dot product matching scores in order to determine which threshold yielded results with most true positive compound annotations and the fewest false positive identifications.
With respect to P-value threshold selection at each stage, a lenient first-stage threshold was used to capture most true positive associations at the expense of some false positives.
Most true-positive cases detected by MS/MS analysis of amino acids and acylcarnitines present with almost self-evident profiles that should not constitute a diagnostic challenge for the traditional cutoff-based system.
Additionally five Indel mutations identified within homopolymer regions with the most reads showing missing bases, thus being the most likely true positives, where also verified as described above to validate the assumption of classifying them as false positives.
Most of true positive cases (10/11 patients) presented a PSA ≥ 1 ng/ml, while approximately half of the false positive cases (5/11 patients) presented PSA below 1 ng/ml.
In fact, most of true positive cases (10 out of 11 patients) were associated with a PSA serum level ≥ 1 ng/mL, while approximately half of the false positive cases (5 out of 11 patients) presented a serum level of PSA below 1 ng/mL (see Fig. 5 and 6).
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