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Although most trials use equal randomisation (such as 1 1 for two groups), it is helpful to provide the allocation ratio explicitly.
As most trials use functional measures, which include pain, rather than specific pain outcomes, it was not considered possible to include pain as a separate effectiveness outcome.
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Most trials using DES enrolled selected patient and lesion subtypes, and primary endpoint focused on angiographic metrics or relatively short-term outcomes.
Most trials used supervised exercise intervention as part of or in addition to regular training [12,50,51,53,54].
Thus far, most trials using DC-vaccines have been conducted in the palliative setting of metastatic or locally advanced disease.
Most trials used placebo or no treatment as a control.
Most trials used electronic central random sequence generation.
Most trials used simple two-arm designs and focused on systemic cancer treatment such as chemotherapy.
Most trials used appropriate methods for randomisation or at least stated that they were randomised.
Most trials used appropriate methods for sequence generation or at least stated that they were randomised and concealed allocation.
Most trials used conventional fractionation, and some trials compared hypofractionation (2.7 4.5 Gy f−1) to conventional fractionation (1.8 or 2 Gy f−1).
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