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That's because most trials so far have focused on ketamine's effect on major depression, and the two don't always go hand-in-hand.
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The fact that most trials have so far been performed with end-stage cancer patients can largely account for this deficit.
Nevertheless, most trials performed so far that addressed the effects of PEEP on outcomes in ICU patients without ARDS were relatively small and mainly assessed other outcomes than mortality, for example development of pulmonary complications [8].
Plus, until the 1990s women were excluded from most drug safety trials, so relatively little is known about the specific ways they react to disease and pain and the medicines used to treat them.
Most of the trials so far focused on targeting single (early) pro-inflammatory mediators.
In Europe and America, meanwhile, Nokia, the world's leading handset-maker, is also testing mobile TV services: the most elaborate trial so far, with 500 users, will start soon in the English city of Oxford, in conjunction with O2, a European operator.It is not just mobile operators that are suddenly interested in TV.
The most rigorous trial so far was by Hagen et al, 14 who randomised 447 women with symptomatic stage 1-3 prolapse to pelvic floor muscle training or a lifestyle leaflet.
But even at the time, it was clear that the fault lay with gross mismanagement of the case, not with the jury.A few weeks later, Lord Woolf, the Lord Chief Justice, issued guidelines to streamline all complex criminal trials so that most last no longer than three months, or six months in exceptional cases.
It is not possible to study such rare events in prospective trials, so our most valuable insights come from the detailed analysis of adverse events.
So far, most trials of adenoidectomy have been performed in children with recurrent acute otitis media or persistent otitis media with effusion and otitis media was studied as the primary outcome.
As outcome of patients with locally advanced and metastatic pancreatic cancer is different (Louvet et al, 2002) and most trials combined both groups of patients so far, only patients with metastatic disease were included.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com