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The only RoB domain where most trials reported information was incomplete outcome data.
Most trials reported separately on anti-nausea and anti-vomiting data.
Most trials reported length of hospital stay after randomisation as a mean or median value without standard deviations.
24 Most trials reported complete outcome data: two trials insufficiently reported on recruitment, attrition, and exclusion to permit judgment.
25 Most trials reported some assessment of pain (general or specific to the neck) (15 trials), and range of movement (ROM) (13 trials).
It was easy to blind participants and providers, and most trials reported that people were unaware of the treatments being provided.
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While most trials report effects on pain or activity limitation, few have measured changes in movement or postural patterns.
There are very few RCTs that have looked at the impact of periodontal care on stillbirth or perinatal mortality, with most trials reporting preterm birth as an outcome.
In general, MSCs appear to be well-tolerated, with most trials reporting lack of AEs in the medium term, although a few showed mild and transient peri-injection effects.
Again, sample sizes ranged from a low of 14 to a high of 232, but the duration of follow-up was more homogenous with most trials reporting 12 months of observation.
The SITS-MOST trial reported in 2008.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com