In most clinical trials performed in this area, often burdened by severe methodologic limitations including excessive clinical heterogeneity, investigators use different definitions of SE (and its stages), adopt inappropriate comparators, or use unclear methods of data presentation [ 35– 37], so that reaching definite evidence is an extremely challenging task.
In this paper we will examine some of the most recent randomized trials performed in Intensive Care, analyzing their premises, hypothesis and outcome.
As most randomized controlled trials performed in the early '90, this study reflects the methods for diagnosis, staging, treatment delivery and outcome measurement that indicate clinical practice during that period.
It, moreover, serves as a stratification parameter in most randomized therapy trials performed in stage-IV melanoma and may also be used to monitor therapy response in these patients.
Most trials were performed on adults who were healthy, were not elderly, and were not at high risk of complications of influenza.
Similarly, trials that were considered most central are the trials performed by ECOG Eastern Cooperative Groupp) and studied curative/definitive type of treatments.
Since mid-shaft clavicular fractures generally unite with most of the treatment modalities, clinical trials performed to compare these therapeutic options are rare.
However, more and more data suggest that ICL670, and probably L1, can be employed as effective alternative drugs, although it should be pointed out that most of this information stems from trials performed in non-MDS patients [ 42– 42].
The 4CMenB formulation has proven to be immunogenic in adults, adolescents, and young infants with a well characterized tolerability profile in clinical trials performed in the most susceptible age groups.
