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One is that, as the US trial suggests, implanting cells inside the human brain is even more of a hit-and-miss affair than most trials of new therapies; even if it works, the mechanisms of the brain are so complex and mysterious that the scientists will have trouble saying exactly why it works.
Most trials of neoadjuvant chemotherapy were closed when the positive studies of adjuvant chemotherapy were published.
Risk of bias was high for most trials of all programs.
It is quite possible that if most trials of mammography were conducted in Nigeria instead of Sweden, there would have been little if any benefit shown and mammography would not be a common practice today.
Several prospective, observational studies find higher B vitamin intake to be associated with lower risk of dementia; other studies, including most trials of B vitamin supplementation, have observed no effect on cognition.
Most trials of neoadjuvant or adjuvant chemotherapy have shown no significant improvement in survival, but many of these studies had suboptimum design, evaluated chemotherapy that was less effective than regimens in current use, and had sample sizes that were too small for important changes in survival to be detected or ruled out.
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In the early overview analyses, however, relatively small numbers of premenopausal women were randomized in trials of tamoxifen, and most trials were of 1 2 years of therapy.
In most trials Quality of Life is collected only up to progression.
5 85 Most trials allowed combination of oral anti-diabetes interventions and insulin.
Most trials recruited women regardless of oestrogen receptor status.
Most trials recruit heavier smokers irrespective of setting.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com