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In most trials not specifically addressing the effects of LTAs on atopy or asthma these conditions were randomized between the treatment groups or sufficiently addressed as a patient subset so as to balance the effects of these conditions on patient outcomes.
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We deemed exclusion on the basis of accuracy of diagnosis (as stated in the protocol) as not worthwhile because most trials did not explicitly state whether the diagnosis was made by a physician.
The extent to which the treatment effect varies across clusters can have a major impact on the interpretation of a trial's results; however, there is often not enough information to obtain a precise estimate of the clustering effect, since most trials are not powered to detect this variability [ 7].
Third, most trials did not stratify study patients according to their immunological state and the efficacy of the immunological intervention was not tested or reported.
Most trials resemble not grand dramas but factory farms.
Most trials did not report the number of patients with full thickness burns.
Of note, most trials did not use the AR antagonist bicalutamide.
STAT has been identified as a promising target for antitumor drugs, but to date most trials have not been successful.
Most trials did not report on length of admission to hospital in a manner that could be pooled.
The definition and classification of injurious falls varied substantially and most trials did not provide a reference for their definition.
Moreover, most trials would not meet current methodological standards because 80% (16/20) of placebo controlled trials were completed at least 20 years ago.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com