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Most trials focused on intermediate or surrogate outcomes of unclear clinical importance.
As most trials focused on knee osteoarthritis, in this sensitivity analysis we restricted the network meta-analysis to knee osteoarthritis trials only.
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Admittedly, it is not easy to find studies that include large numbers of people with mild to moderate depression; most trials focus on severely ill patients.
In effect, most trials focus on maintaining the high level of cure, while reducing the long-term effects of treatment.
Ben A. Barres, chairman of the neurobiology department at Stanford University's medical school and a pioneer in glial cell research, notes that 1,000 trials for stroke drugs have failed, and most of the trials focused exclusively on neurons.
However, most of those trials focused on the outcome of immediate emergency treatment before surgical intervention.
Most vaccine trials focus on patients with advanced cancer (therapeutic vaccines) and have largely produced disappointing results.
3 However, despite much progress in the laboratory, so far only a few HDP-derived compounds have progressed into the clinic, with most clinical trials focusing on topical rather than systemic applications (Table 2).
As a result, most trials have focused on such patients and on younger, healthier subjects than the average patient.
Most trials have focused on the effects of fish oil on people who have had a history of heart trouble.
MOST trial watchers focused their attention yesterday on Centre Street in Manhattan.
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