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However, CGI improvement, which is a common categorical outcome measure used in most trials, did not differ, with 47% on citalopram and 45% on placebo being considered much or very much improved (not significant; Wagner et al, 2004).
Most trials did not report the number of patients with full thickness burns.
Of note, most trials did not use the AR antagonist bicalutamide.
Most trials did make an attempt to prevent contamination between clusters, though.
Most trials did not report on length of admission to hospital in a manner that could be pooled.
The definition and classification of injurious falls varied substantially and most trials did not provide a reference for their definition.
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And most trials do enroll experienced users.
9 10 11 As Schwartz and Lellouch wrote: "Most trials done hitherto have adopted the explanatory approach without question; the pragmatic approach would often have been more justifiable".
In the burst of RCTs preceding Cochrane, the Omega World line was that these most recent trials did not show benefits because things such as statins, stents and other forms of cardiovascular intervention masked the anti-inflammatory effect of fish oil pills; earlier RCTs had shown a fairly significant effect, but none of those treatments existed at the time of those trials.
Most discarded trials did occur in the first block, indicating that participants may have been partly acclimating to the task and interface (32 vs. 15 vs. 18, χ(2) = 7.6, p<.05).
However, in contrast to XR, the MRI scoring method that was used in most clinical trials did not include cartilage loss.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com