Most trials comparing the preventive effect of CHX varnish were conducted on school children, adolescent or adults.
38, 39 Additionally, most trials comparing gonadotropins do not report on cumulative live-birth rates per treatment program, embryo quality, or dropout rates in subsequent frozen cycles.
In line with our own results, most trials comparing a DPP-4 inhibitor with SU, in combination with metformin, demonstrate a slightly higher risk of hypoglycaemia in the latter group [ 15- 18].
Most trials comparing heparin to citrate in CVVH had small numbers of patients and mainly focused on filter survival [ 10– 13], and only two had mortality as an outcome measure [ 14, 15].
18 19 20 To date, most trials comparing combination therapy with aliskiren and renin-angiotensin system blockers have focused on surrogate outcomes and have been underpowered to provide robust estimates of adverse events.
Most drug trials compare the drug to a placebo.
Our interface was designed to compare only two drugs at a time, but this is not a major limitation, because (i) most clinical trials compare no more than two drugs, (ii) for safety evaluations, our prototype could easily be adapted for the comparison of more than two drugs, by adding additional columns if similar types of data are available for all the drugs.
Moreover, the most recent trials comparing PCI with CABG failed to provide a clear superiority.
Intention-to-treat analysis in most screening trials compares no invitation (control) to invitation to screening (intervention).
Moreover, diagnostic angiography preceded randomisation in most strategy trials comparing revascularisation with medical treatment, which is likely to have resulted in the exclusion of higher risk patients.
