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The purpose of this review is to address the reasons for our failure to objectivate an improvement in the cure of gastric cancer with adjuvant treatment in most trials, and to consider potential solutions.
For example, supplemental vitamin D, which might prevent falls in older persons, reduced the risk for falls in a few trials, had no effect in most trials, and increased falls in 1 trial.
However, interpretation of the results is hampered by the limited sample size of most trials and the heterogeneity in design.
The reduction in mean number of migraine attacks per month was the primary efficacy endpoint in most trials, and therefore the measure on which they were powered.
Secondly, the data of echocardiographic parameters were partially reported in most trials and were not consistently provided in a poolable format (Table 3).
This is consistent with most trials, and no second peak has been observed in similar patient populations, suggesting that the TARGIT-A trial results are stable.
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Table 3 shows consistent components of risk of bias across the trials, including performance and detection bias due to inadequate blinding in all of the trials, and selection bias due to a lack of transparency regarding sequence generation in most trials [12,51,52,55,56] and of allocation concealment in all trials.
In most trials inclusion and exclusion criteria were not specified.
None the less, DCV have yet to prove an effective cancer treatment modality and most trials have been small and uncontrolled.
Most trials were small and recruited between 10 and 100 participants (50.5%).
Most trials were small and had some design limitations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com