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Most trials already include a predetermined sample size calculation, which includes estimation of an anticipated intervention effect.
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Most trials had already been rated at least twice by trained evaluators of PEDro database (http://www.pedro.fhs.usyd.edu.au/).edu.au/
Furthermore, in most trials summarized in Table 1, patients were either already on CSII before randomization or were put on CSII during the trial.
Seven major companies have entered the fray, with multiple phase III registration trials already underway in a variety of malignancies, most notably melanoma, RCC, and NSCLC (Table 3 ).
Unfortunately, in most trials as well as in real life, lesions nowadays are usually detected when there is already considerable visual loss.
But most trials fizzled.
Most trials investigated drugs.
At the start of the trial, already most nurses and physicians expected SDD to effect patient outcome and this group had a relative increase of 15% towards the end of the trial.
Can we just fast forward to his trial already?
Most of the already published trials have demonstrated safety and feasibility of cell therapies in these clinical conditions.
Most had already been withdrawn.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com