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4 Numbers needed to harm are therefore lower in routine settings than in most trial populations.
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This lack of statistical power is a major reason that most trials attempt to only qualitatively compare the relative risks in the overall trial populations and various subgroups.
26 The relatively low overall rate of increase of disease stage in our trial population most likely reflects use of combined therapy of tacrolimus with azathioprine and steroids and/or the generally lower trough levels of tacrolimus achieved.
No meta-analyses were possible exclusively on a whiplash associated disorder II population, as most trials included combined classifications of whiplash associated disorders in their populations.
Also, most trials included relatively small study populations.
Clavicle fractures have a bimodal age distribution [46, 47], but all papers limited the trial population age, excluding most or all of the older group, reducing generalisability, as findings cannot be universally extrapolated.
Future studies should therefore make a greater effort to enrich their trial population with the most appropriate patients - namely those who have a tumour molecular profile likely to predict benefit from targeting the given pathway.
Most trials have resulted in reduced Aedes populations, Oxitec has said.
Secondly, most trials were based in high risk populations attending sexual health clinics.
Despite controversy regarding optimal doses, meta-analyses have repeatedly shown benefits on mortality and infections of these studies [ 116- 118], most trials having been conducted in European populations.
In most trials in critical care medicine the target population is heterogeneous, also including genetic polymorphisms.
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