Sentence examples for most synonymous mutations from inspiring English sources

Such values indicate the fact that most synonymous mutations occur at the 3rd position, with a few at the 1st position and none at the 2nd as also observed in Australian fish [143].

The only requisite assumption is that most synonymous mutations are selectively neutral.

Neutral mutations, such as most synonymous mutations, or some nonsynonymous mutations that do not alter gene function, can also be retained.

This greater accuracy derives from the accumulation of mutational events across 300,000 generations (summed over the eight replicate populations) and over the entire genome, coupled with precise knowledge of the number of elapsed generations and the reasonable presumption of selective neutrality or near-neutrality for most synonymous mutations.

This value is 6.1-fold higher than the rate of 0.00041 from Wielgoss et al. (2011), who commented in their abstract that "our estimate represents the most accurate measure of bacterial base-substitution rates available to date" and in the text that "our estimate is probably more accurate" applying "the reasonable presumption of selective neutrality or near-neutrality for most synonymous mutations".

While fixation of deleterious mutations is reduced by outcrossing and large effective population size, most non-synonymous mutations are likely beneficial mutations in the conifer phyla.

The reasons for this observation are unclear, but the theoretical prediction is based on an assumption that most non-synonymous mutations are deleterious.

The Z test of selection and Ka/Ks ratios demonstrated a deficit of non synonymous mutations in most of the genes (immune related or not).

In addition, the distribution of synonymous and non-synonymous changes in the MCP gene revealed that the iridoviruses were evolving slowly, and most of the variations were synonymous mutations.

Because advantageous mutations undergo fixation in a population much more rapidly than neutral mutations and because most synonymous substitutions may be assumed to be neutral, the rate of nonsynonymous substitution should exceed that of synonymous substitution if positive Darwinian selection plays a major role in the evolution of a protein-coding gene.

Although the number of SNPs was higher in ORFs than in UTRs, synonymous mutations predominated in most cases.