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Some treatments have been assessed in randomized trials, but most such trials have been too small to detect treatment effects of a magnitude that would be realistic to achieve with a single intervention.
In 1993 and before clustering was ignored in most such trials.
This 'delta inflation' is a potential reason that most such trials fail to demonstrate efficacy.
8 The under-representation of older people in clinical trials of antidepressants and the fact that most such trials are short term make deriving reliable or precise estimates of the incidence of adverse events in this group difficult.
5 Most such trials also exclude the most severely disturbed individuals, for example, those with comorbid personality disorder (PD) who are known to respond less favourably to existing treatments for acute depression, notably cognitive behavioral therapy.
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But both of the defendant's points were rejected in another of the testy exchanges between judges and accused that have become a staple of the most important such trial since Hitler's henchmen faced justice at Nuremberg.
7 Although our search may have retrieved some randomised phase 2 trials, most such studies are not randomised trials.
Such trials are most feasibly done in chronic conditions, where little or no washout period is needed between treatments and treatment effects are identifiable in the short-term, such as pain or reliable surrogate markers [ 47- 49].
Most such cases are settled before trial.
But most such leaks tend to be trial balloons of sorts -- meaning it's looking like Raúl may be readying his long-suffering public for some big changes, changes he has to know are necessary for the régime's long-term survival -- changes perhaps following the lead of America's bosom trading partners, Communist China.
Currently, the most common approaches are either ignoring such trials or for each trial with a missing SEM, finding a similar trial and taking its SEM value as the missing SEM.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com