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The pharmaceutical industry has become the law's most successful target because the government now buys far more pills than bullets, and because fraud in health care is common.
The peroxisome proliferator activator receptor-γ (PPAR-γ) remained the most successful target for management of diabetes mellitus.
Even though the game under discussion was basically gender neutral, she suggested it was fine to have a box design which appealed mostly to boys because they had historically been the most successful target market for science titles.
As a central regulator of the pathway and a readily accessible cell surface component, Smo has been the most successful target for developing Hh antagonists.
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On Friday, an advisory committee to the Food and Drug Administration recommended approval of dasatinib, a drug for certain leukemia patients who are no longer helped by Gleevec, one of the earliest and most successful targeted drugs.
Even the most successful targeted therapies lose potency with time.
Although endocrine therapies are among the most successful targeted therapies in oncology, a significant subset of ER+ breast cancers have become resistant to them.
Interestingly, the estrogen receptor alpha and HER2/ERBB2, the major parameters characterizing 3 of the 5 different classes, are the goals for the most successful targeted therapies in breast cancer, underlining a fundamental role in biological control.
As an intensively used production platform for recombinant proteins and because of the ease to manipulate the genome by homologous recombination, yeast (particularly Saccharomyces cervisiae, Pichia pastoris) was one of the first and most successful targets of glycoengineering.
Based on these findings, we asked whether BBR inhibited the Hh pathway activity by targeting Smo, which is the most successful molecular target for developing anti-cancer drugs in Hh pathway.
My most techy paper (and also one of the most successful), on target zones (pdf and very, very wonkish) began with pictures; I didn't know any stochastic calculus, and picked up the little I needed after I had already figured out the paper's main results.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com