The most successful type of structure prediction, known as homology modeling, relies on the existence of a "template" structure with sequence similarity to the protein being modeled; structural genomics' goal is to provide sufficient representation in solved structures to model most of those that remain.
This review discusses the structural design of the most successful monodentate phosphines and, following a historical line, reports on their application in the asymmetric hydrogenation of CC and CO bonds.
While recent biomedical interventions - like male-circumcision [25], the development of a vaccine [26], microbicides [27] and pre-exposure chemoprophylaxis [28] – constitute important advances, they are going to be most successful when juxtaposed with relevant behavioral and structural changes [24].
Morton and Berry's caramels, which use condensed milk, golden syrup and (again) lots of butter, prove most successful; soft rather than chewy, but with enough structural integrity to keep their shape.
As shown in the recent PRD specificity prediction challenge of the DREAM4 competition [ 70], most likely a combination of structural and statistical methods will be most successful at predicting specificities.
Industrialization, as structural transformation of economies, has been the most successful vehicle for the development of nations in the world.
AFM is one of the most successful techniques for the characterization of surfaces and is routinely used to describe structural details with nanoscale resolution.
This structural change seems to be targeted at helping Tencent grow revenue beyond the consumer space, where it has seen tremendous success with WeChat, China's top messaging app, perhaps its most successful product.
The fluoroiodane 1 is an air- and moisture-stable crystalline compound and structural analogue of the Togni reagent,[ 2a, 22] which has been one of the most successful electrophilic trifluoromethylating reagents in organic synthesis.
