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Finally, as the clinical situation of these studies evolves and we make observations not just about toxicities, but also on measures of responses, then we can target quantities other than the MTD, in particular the MSD (the most successful dose), which combines information on toxicities and responses together.
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While the most successful ad campaigns have a much needed dose of humanity, these advertisers often try to pull at our heartstrings rather than put themselves in the place of the people they're showing: the perfect family reunited over the perfect cereal, the women who suddenly feel empowered and beautiful after the right personal care product.
Up to now, the most successful method of preventing neurotoxicity is still dose reduction or withdrawal of BTZ.
All of the drugs used in the survival assay were trialled at a range of concentrations to construct dose-response curves, from which the most successful (activity versus toxicity) concentrations were taken forward (0.5 μM to 3 μM).
The ip model has been the most successful for determining carcinogenicity of inorganic fibers and establishing dose-response relationships; but to determine the possibilities and limitations of this test model, very high doses of nonfibrous silicon carbide and of a slightly durable glass fiber type were injected ip in Wistar rats.
On Dose's first day of existence, its most successful list was called "23 Photos of People from All Over the World Next to How Much Food They Eat Per Day".
Like all Blume's most successful books, it was a pre-teen insight into a teen world: first bras, first kisses and a healthy dose of existential angst.
"The Village" is his heaviest dose of anti-Prozac to date, yet still it has risen, however briefly, to become the most successful film in the country.
Most successful companies do this.
The most successful performers improvise.
What organizations have been most successful?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com