Nucleoside analogues have been the most successful antiviral compounds.
Temsirolimus (Torisel®, Wyeth pharmaceuticals), an analog of rapamycin targeting mTOR [5], represents the most successful developed compounds targeting this pathway, which has been approved for the treatment of advanced kidney cancer.
To date, the most successful antiviral compound with mutagenic activity in cell culture is purine analogue ribavirin (Crotty et al., 2000; Maag et al., 2001; Brochot et al., 2007; Perales et al., 2009; Moreno et al., 2011).
Interestingly, most of the successful compounds are based on an indole scaffold, including a compound that has been shown to bind to NHERF1 and inhibit the interaction with the C-terminus of cystic fibrosis transmembrane regulator.
A direct, solvent-free impregnation technique turned out to be the most successful for all organometallic compounds and provided homogeneous inorganic cover layer on the surface of purified MWNTs.
One of the most successful is a chemical compound under the trademarked name of Ambrox, which was devised by Firmenich's fragrance chemists in the 1950s and featured, I am told, in Dolce & Gabbana's perfume Light Blue.
TaxKB is a single-information portal for the most successful blockbuster natural drug compound ever discovered, namely, taxane.
This review describes most successful mitochondrially-targeted redox-active compounds, Mn porphyrins and MitoQ10 in detail, and briefly addresses several other compounds that are either catalysts of O2− dismutation, or its non-catalytic scavengers, and that reportedly attenuate mitochondrial dysfunction.
All told, Gove's traditionalism perhaps leads him to fixate on schools that cater for 11- to 18-year-olds, while some of the country's most successful institutions are overlooked (to compound their pain, unlike schools, sixth-form colleges must also pay VAT).
