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Perhaps the most substantial single obstacle to progress of space exploration and utilization of space for human benefit is the safety & reliability and the inherent cost of launching to, and returning from, space.
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But the single most substantial new acquisition on view here is a complete set of James McNeill Whistler's "Naval Review" etchings.
High parity birth (birth order >3) was the most substantial high risk factor in the single risk category, consistent with the observation that Burkina Faso has a high TFR.
The changes, which are shaping up to be the most substantial alteration ever to a campaign calendar in a single election cycle, have heightened the volatility of the most wide-open presidential race in 50 years, one with large and well-financed fields of contenders.
Cowell also embodies Frost's other most substantial legacy: the realisation that the UK and US television schedules can sometimes be shrunk into a single, richly exploitable market.
China's increase has been the most substantial.
Portraiture accounts for the most substantial works here.
This will be the most substantial change since the 1940s".
The most substantial additions unveiled yesterday are underground.
The most substantial difference is related to the substances involved.
Marius the Epicurean (1885) is his most substantial work.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com