The most substantial shifts occurred for Thy9 and Gua17, which inverted their preferences from C3'-endo and C2'-endo sugar puckers to C2'-endo and C3'-endo sugar puckers, respectively.
The most substantial shifts were with ambiguously placed markers, which can be included at any one of several positions without affecting map likelihood.
This is a substantial shift since the most important class of algebra of observables for quantum mechanics was thought at the time to be the set of bounded operators on an infinite-dimensional separable Hilbert space, which is a type-I∞ factor.
The school shooting that took place in Parkland, Florida, earlier this year launched a new generation of gun control activists, inspired walkouts and marches, and sparked the most substantial ― and long-lasting ― shift in public opinion on guns in recent years.
The most obvious response to harvesting was a substantial shift in core range position and, in some cases, a large (>100%) increase in home range size.
We have previously shown that the most substantial change in α-synuclein is a shift from the soluble to the SDS-soluble membrane-associated fraction over the course of PD [ 10].
The most substantial decreases were observed in the two provider groups that shifted the first hepatitis B dose from birth to 5 6 months of age.
For most brands online video won't begin to truly replace TV until there's a much more substantial shift in consumer media consumption, but very few brands are yet maximising the huge opportunity that is already there.
In terms of change over time, the most fundamental shift of travel behaviour in cities over the last five decades is linked to the rapid increase in global levels of motorisation, and a substantial shift away from non-motorised and public transport.
That is a substantial shift in British politics and a healthy one.
