Sentence examples for most substantial challenge from inspiring English sources

However, the task of distinguishing pathogenic mutations from rare sequence variants is not easy and is the most substantial challenge to the next decade.

However, the task of distinguishing pathogenic mutations from RSVs is not resolved and is perhaps the most substantial challenge to the next decade.

In particular the HRH dimension of NHI, specifically the proposed staffing of underserved districts and facilities in rural areas, will indubitably pose a most substantial challenge to its realisation.

It is sure not to be a smooth run; its HRH dimension, especially the staffing of underserved districts and facilities in rural areas, will indubitably pose the most substantial challenge to its realisation.

Confident of his prowess, United believe De Gea's currently faltering grasp of English presents one of his most substantial challenges.

One of the most substantial challenges to Anglo-centric and even racist discourses regarding men and violence has come from South Africa, with the development of a rich scholarship on these issues (Morrell, Jewkes, and Lindegger 2012).

One of the most significant challenges in teaching an introductory-level applied computing course is that students are not expected to have substantial math and science experience.

However, although many gene sets covering a large panel of biological fields are available in public databases, the ability to generate home-made gene sets relevant to one's biological question is crucial but remains a substantial challenge to most biologists lacking statistic or bioinformatic expertise.

Neither of the two games is likely to pose a substantial challenge for the most beginner-level gamer, as both are designed to be played to their storyline climaxes.

The fourth difficulty was the most substantial, but it should probably be understood as the challenge of the meal, rather than a mere drawback.

The HLA system is the most polymorphic of all human genetic systems and this diversity raises a substantial challenge in the identification of matched donors.