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Numerically, the most substantial alterations were the change in the genus Bifidobacterium (e.g. Bifidobacterium adolescentis), which increased approximately 10 fold (from 2 3% to 18 30%) in three subjects through RS4.
At 12 weeks of age, the most substantial alterations to metal concentrations were observed in the spinal cord.
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The changes, which are shaping up to be the most substantial alteration ever to a campaign calendar in a single election cycle, have heightened the volatility of the most wide-open presidential race in 50 years, one with large and well-financed fields of contenders.
The most substantial alteration takes place in the estimated effect of white cheese, where the measurement error corrected analysis shows a non-significant protective effect.
This will be the most substantial change since the 1940s".
The dual front-facing camera is the most substantial change.
Importantly, in over 85% of instances (first two lines in "RNA not conserved" portion of fig. 1) when a C. elegans nested RNA did not have an ortholog in C. briggsae, the host gene had a clear ortholog, implying that losses and gains of nested genes most often proceed without substantial alterations of the host genes.
In most non-athletic AMBRII patients, MR arthrography shows an increased capsular volume but no or little substantial alterations of the intraarticular structures.
To be fair to Mr. Joffé, however, the movie has reportedly undergone substantial alterations since its filming in Moscow in 2005.
Syriza may secure a few minor tweaks to the pace and nature of the reform programme – but these won't be substantial alterations.
But after the scholars obtained a copy of a draft screenplay, criticized it severely and proposed substantial alterations, a fierce war of spin and counterspin broke out.
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