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The quality of most studies was limited by small sample sizes and cross-sectional designs.
Regarding age distribution, the average age of presentation in most studies was between 30 and 50 years [5, 6].
For example, the non-dividing property of RPE cells can impede the transfection efficiency which in most studies was ignored by using immortal cell lines.
First, the statistical power of most studies was rather low.
However, the methodological quality of most studies was poor.
The length of follow-up for most studies was 6 12 months.
The duration of exposure in most studies was short (Table 1).
One issue common to most studies was the lack of compliance to the prescribed dietary intervention.
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Similarly, most studies are plagued by confounding variables such as not observing the quality of hospital management.
Most studies are economic evaluation of trials.
Most studies were of retrospective character.
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