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Additionally, most studies requiring an animal model for the study of F. tularensis are conducted in mice due to their ease of use.
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Most studies required an average attack frequency of different intervals between 3 and 12 attacks per month.
However, most studies require detailed knowledge of the DNA sequences from target species prior to setting-up the methodology and in insecure cases the final assignation should always be validated afterwards by DNA sequencing [5], [8].
Most studies required administration of surfactant within 48 hours of the diagnosis of ARDS.
Certain studies tested in an open-book format [ 19], allowing participants access to trial information, while most studies required participants to work from memory alone.
Although most studies required blood cultures to be positive <48 hours of patient admission (1, 13 ), others have used <72 hours (28 ) or <24 hours (7, 11 ).
6 8 Most studies required patients to be treatment naïve and have macular oedema with retinal thickness measuring at least 250 or 300 μm on optical coherence tomography.
Despite sample sizes ranging from 30 practices to 137 practices, and a wide range in recruitment rates, most studies required over nine months to recruit participants.
Although most studies required a 'curative' resection or treatment protocol for inclusion criteria, a number of patients inevitably had evidence of micrometastasis or regional metastatic disease on further evaluation.
In particular, measures of variance of the data were unavailable for most contributing studies, requiring that weighting be done by sample size alone [ 18] with consequent limitations upon the methodologies that could be used to present uncertainty intervals around both the individual studies and the summary estimates.
Most genetic studies require tens of thousands of participants to carry enough statistical power to be considered meaningful.
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