Most studies characterizing the biology of IL-27 have been performed on lymphocytes where this cytokine plays a major role in immune regulation.
Most studies characterizing the biophysical and pharmacological properties of this current have been conducted on human cells of hemopoietic origin, such as macrophages, lymphocytes, leukemia cell lines and granulocytes (for a detailed review on IHvs see: Ref. [1]).
Most studies characterizing expression in response to regulatory elements are performed in embryonic tissue, showing specific expression patterns during development.
Most studies characterizing the effect of insulin on IOP and ocular fluid dynamics have reported averages over many hours to days.
Whereas the functional effects of specific PTMs are the current subject of intense investigation, most studies characterize histone PTMs/variants in a non-temporal fashion and very few studies have reported kinetic information about these histone forms.
However, while most studies characterize epigenetic alterations in cancers using cancer cell lines or the entire tumor, cells within a tumor display a wide degree of heterogeneity, and not all of them have the ability to initiate and sustain a tumor [ 16, 17].
Most studies have characterized SMG neuron activity with electrodes ex vivo (for example, [32]) or extracellular recording in vivo [33].
Previous studies characterized most of the used biomarkers as suitable markers for detection of ACR: percentage of CD25-positive T cells correlated with ACR after transplantation [ 15].
Currently, most studies that have characterized IF have focused on the permeability of ECM or shear stress distribution on the cells, but less is known about the prediction of shear stress on the individual fibers or fiber networks despite its significance in the alignment of matrix fibers and cells observed in fibrotic or wound tissues.
Unfortunately, most studies have been characterized by either a relatively small or selected study collective, or by a gender imbalance [ 6, 14, 15, 28– 30].
