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In this study we screened for the six most studied virulence factors.
Among the most studied virulence factors are the Francisella pathogencity island (FPI) genes, which encode a secretion system required for phagosome escape and intramacrophage growth [15].
The secreted aspartic proteases (Saps) are among the most studied virulence determinants in Candida albicans.
The most studied virulence factor of dermatophytes includes enzymes that are released during the infection process allowing the utilization of the host tissue nutrients, enabling fungal invasion and dissemination [ 27].
The most studied virulence factor of H. pylori is cagA, which is located at the end of an approximately 40-kb cluster of genes called cag pathogenicity island (PAI).
This difference was mainly due to the fact that the majority of the strains from bloodstream infections presented genotypes, 10-10 and 10 12, clustered in group II, while isolates from oral infection presented genotypes 8 10, clustered in group I. Secreted aspartyl proteases are among the most studied virulence factors in C. albicans.
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Bacterial alginate is one of the most studied P. aeruginosa virulence factors [2], with confirmed roles in protection of bacteria from host immune defenses [3], [4], exacerbation of inflammatory tissue damage [5], and contribution to bacterial resistance towards conventional antibiotic therapies [6], [7], [8].
The VacA vacuolating cytotoxin, thought to cause detectable alterations in gastric epithelial cells and immune cells, is also one of the most studied H. pylori virulence factors [ 7].
As a result of the devastating CF infections caused by the B. cenocepacia ET12 strain, it has become one of the most studied Bcc bacteria in terms of virulence [ 7] and antimicrobial resistance [ 8, 9].
Type 2 diabetes is the most studied diseases, associated with 514 SNPs across 397 studies.
The most studied animals were chimpanzees, with 1,855 mentions, and leopards, with 1,241 mentions.
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