However, physical and sexual abuse are also the most frequently studied subtypes of childhood trauma, and only a few studies have paid any attention to emotional abuse or neglect (Daruy-Filho et al. 2011).
Although this review article is focused on glial purinergic receptors involved in pain transmission, a brief summary of data on neuronal P2X3 subtype, the most studied P2X receptor subtype involved in nociception, cannot be omitted.
Because of our stratification of breast cancers into many groups, we share a limitation of most studies by molecular subtype, namely, small sample size within strata resulting in imprecise effect-measure estimates for each subtype.
The 5-HT1A receptor subtype is the most thoroughly studied serotonin receptor subtype.
However, most studies include only subtype B strains, while it is known that especially the env region is very divergent among subtypes.
Most studies to date reporting subtype frequencies have been quite limited, with fewer than 200 AS cases reported.
Although suggestive of differences in the effect of age at menarche by histologic subtype, most studies had low power and only one study was restricted to postmenopausal women [ 19].
Until recently, most studies using IHC to assign molecular subtype status to breast cancer have not used Ki67 to discriminate between Luminal A and B and rather only used Her2 status [ 7].
Still, it is difficult to compare the studies because of different classifications for lung cancer subtypes, and because most studies have only a small number of cases for analyses.
For the present study we chose to analyze four particular variable gene loci: the most commonly studied UL55/gB, of which one subtype (gB-1) is the vaccine strain, the truncated TNFα receptor-like gene UL144 [9], and the alpha chemokine ligand UL146, the most variable of all CMV genes with 14 known subtypes [10], [11].
