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Its apo, AMP-bound and the ternary structures have been determined, making it the second structurally most studied member of the APH family [11].
The most studied member of this group of BVMOs is CPDMO, a BVMO from Pseudomonas sp. HI-70 (Iwaki et al. [2006]; Beneventi et al. [2009]; Fink et al. [2011]).
BLAST search against database sequences revealed highest identity (63%) with the unstudied putative BVMO from Gordonia terrae NBRC 100016 (ZP_09801205), while among characterized BVMOs, 41 44% sequence similarity was observed with a group of BVMOs whose most studied member is CPDMO and that like BVMO4 are about 600 amino acids long in their primary structure.
TG2 is the most ubiquitously expressed and is the most studied member of the family.
In the past few years, the immunity to several infections has been demonstrated to be influenced by galectin-3, the most studied member of the galectin family.
Among the nine serotypes, APMV-1 (NDV) is the most studied member due to its importance as a major pathogen of poultry.
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The two most studied members -C/EBPα and C/EBPβ- play important roles in skin homeostasis and their ablation reveals cells with stem cells signatures.
The two most studied members of the family, C/EBPα and C/EBPβ are required for differentiation of adipocytes and hematopoietic cells [3] [6].
The most extensively studied member of the integrin family is the integrin αvβ3.
The most detailedly studied member of this group is the Agrocybe aegerita aromatic peroxygenase (Aae APO), which is secreted by an agaric fungus, the Black poplar mushroom.
The most intensively studied member of the biomedically important dinuclear mAPs is the prototypical secreted Vibrio proteolyticus di-zinc aminopeptidase (VpAP).
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