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The first and most studied example of gene regulation by an enhancer is provided by the β-globin locus; here, the locus control region (LCR) is located 40 to 60 kb upstream from the promoter it regulates.
The most studied example of the potential benefits and unique challenges associated with NDS comes from Google Flu Trends.
The most studied example is endothelial targeting via multiple cell adhesion molecules (CAMs), which mimics the strategy of leukocytes to adhere and traverse the vascular endothelium.
The most studied example is the Pigment Yellow101 (P.Y.101), depicted in Figure 1, which is the onlycommercially available fluorescent yellow pigment that shows strong fluorescence incrystalline state.
Perhaps the most studied example of gradient perception is chemotaxis in certain motile bacteria, which are capable of perceiving and adaptively responding to the spatial attributes of resource gradients, registering nutrient concentrations at different points in time [e.g. 18], [19].
Perhaps the most studied example of nematode aggregation is as a component of a set of related behaviors including social feeding (aggregation on a bacterial lawn), bordering (accumulation at the edges of bacterial lawns), and agitated movement in Caenorhabditis elegans.
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Based on the two most studied examples - IRF5 and STAT4 - it is tempting to speculate that common shared genes are located in the major knots of the signalling cascades.
In most studied examples, the plot of gene expression versus allele size is a concave (Peters et al. 1999) or convex (Vinces et al. 2009) bell-shaped curve or a step-like graph in which expression increases or decreases suddenly at a threshold allele size (Okladnova et al. 1998; Yamada et al. 2000).
The most extensively studied example of a silent uptake into phagocytes is the clearance of apoptotic cells which is a well organized three step process [16].
Probably the most extensively studied example is the bending capability of DNA for its importance in the packaging of the genome into nucleosomes, the chromatin fiber and chromosomes [1], [2].
MHC genes are among the most thoroughly studied example of adaptive molecular evolution.
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