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Mitosis-associated transcripts were most strongly elevated in K5-TGFβ1 lesions, and a comparable trend was evident for K5-Tie2 lesions, and in this regard, the K5-TGFβ1 and K5-Tie2 models were generally most similar to the mitotic gene expression signature of clinical psoriasis (see Figure S12).
In this pathway, the gene most strongly elevated in the insulin-resistant group was LDL-associated phospholipase A2 (PLA2G7 or LDL-PLA2).
The PP-increased score (horizontal axis ) is equal to the average fold-change (PP/PN) of the 100 DEGs most strongly elevated in the meta-analysis.
Since MARK4 was the major isoform present in GVDs and most strongly elevated in AD cases, we chose to continue to study the MARK4 isoform in relation to neurofibrillary changes.
In particular, DEGs most strongly elevated in PP skin (FC > 3) were enriched for genes highly expressed in KCs and epidermis.
We have found that MMP-1 is among the most strongly elevated genes in cells with high metastatic potential and that this expression is transcriptionally regulated by Fra-1 interaction with the AP-1 site of the MMP-1 promoter.
Similar(53)
Three chemical probes (BRD5459, BRD56491, BRD9092) are highlighted that most strongly elevate markers of oxidative stress without causing cell death and may be of use in a variety of cellular settings.
Unexpectedly, INHA, barely detectable in disease-free liver, was strongly elevated in most HCC samples.
Notably, the metabolites most correlated with the first component are tanshinones, whose levels are strongly elevated at 120 hpi and 240 hpi, although increases can be seen as early as 36 hpi.
Small tree and bush densities were strongly elevated at mono-specific compared to multi-species herbivore sites.
In the present study strongly elevated levels of cathelicidin in keratinocytes in psoriatic plaques were confirmed.
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