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Analysis of the superposition reveals that globins are most strongly conserved structurally in the mid-regions of the E and G helices.
The two most strongly conserved elements of the cellular, poxviral and flaviviral enzymes are the SAM-binding pocket determining the position of the methyl group donor and the active site determining the position of the target nucleoside13,14,23.
The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat.
Base changes at the most strongly conserved positions 2 (alanine for thymine) or 5 (guanine for cytosine) of v1 caused this affinity to drop ∼1,000-fold ∼1,000-fold
A single nucleotide change of T to A at the most strongly conserved position of the HNF4A binding site results in reduced transcription of F9.
Surprisingly, several of the most strongly conserved residues in the Gemin2-binding domain of SMN play no obvious role in binding to Gemin2.
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Once again some core components are strongly conserved most notably a G-protein (Rho1), protein kinase C (Pkc1), and a MAP kinase (Slt2).
For example, the proline-rich regions are strongly conserved in most Xins but do not appear to be homologous regions when comparing the Xinα proteins to the Xinβ proteins or when comparing the fish Xins to the tetrapod Xins.
Positional analyses further indicated that most positions are conserved or strongly conserved.
This residue is also strongly conserved among most of the INS-like superfamily of editing domains.
Our results suggest that most Arabidopsis WDR proteins are strongly conserved across eukaryotes, including those that have been found to play key roles in plant-specific processes.
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