Despite the limitations of the study design, however, we found no convincing evidence for a therapeutic effect of thymostimulin used as a single agent, in particular with regards to the most stringent study endpoint overall survival.
Arguably the most stringent study conducted to date to elucidate whether the phenomenon of cell fusion occurs under true physiological conditions was carried out by Nern and colleagues in 2009 [ 31].
On a more conciliatory note, Syngenta told the EFSA it was considering "large-scale" bee-monitoring studies to "close data gaps", despite previous claims its product had been introduced only after "the most stringent regulatory work".
As clearly documented in the work of Kim et al., we used the most stringent EPP value as our study was focused on "strict divergent gene analysis parameter" [ 65].
However, it is unlikely that this explains the difference between euthymic patients and controls on self-report impulsivity measures, as the studies with the most stringent definitions of euthymia did find significant group differences (e.g. Ekinci et al. 2011; Strakowski et al. 2010).
It is worth mentioning that the most stringent assay applied in the present study is the in vitro differentiation assay that corresponds to the teratoma-formation assay in vivo.
Therefore, the study used the most stringent criteria to include only those trauma cases with minor neck injury.
Of interest, the study with the most stringent methods was the only one to show a clinical cure advantage for prolonging β-lactam infusions [ 9].
The present study has provided most stringent support for the assumptions of attentional control theory that in tasks requiring attentional control, anxiety impairs processing efficiency more than performance effectiveness (cf. Eysenck et al., 2007).
The BLAT program was used to extract from the PN40024 genome a total of 1709 copies paralogous to the 13 canonical copies representing the families identified in this study at the most stringent criteria for seeding alignments based on sequences of 95% and greater similarity over 40 bases of length or more.
