The design of the TargetScan algorithm, considered to be amongst the most stringent methods, limits the numbers of in-silico predicted targets.
Of interest, the study with the most stringent methods was the only one to show a clinical cure advantage for prolonging β-lactam infusions [ 9].
In particular, the estimated odds ratios for maternal education remains similar across the two models and similar to those estimated for the larger sample of daughters, suggesting that this association is robust even when the most stringent methods are applied to control for possible confounding in this relationship.
Five sequential filters were applied to the 162,141 candidate genome-wide SNPs for GGGT assay design from F0 (less stringent) to F4 (most stringent) (see Methods).
Using the most stringent "automated scoring" method, 3355, 3401 and 3286 probes were identified as positive with the plate, row and column pools, respectively.
It also is noteworthy that a previous study, which utilized the most rigorous and stringent methods, was the only study to demonstrate a clinical cure advantage in favor of CI administration of beta-lactams [75].
It also is noteworthy that a previous study, which utilized the most rigorous and stringent methods, was the only study to demonstrate a clinical cure advantage in favor of CI administration of beta-lactams [ 75].
As we had three study groups (infertile ART, donor oocyte ART, and fertile control, see ' Methods'), the most stringent approach to determine whether differences exist is ANOVA followed by Tukey's post hoc HSD test to identify which specific groups are responsible for any significant differences.
Traces of dendritically recorded voltage (V) and the first temporal derivative of voltage (dV/dt) in response to a single presynaptic burst of the PP for the events above the upper bound of the 99% prediction band shown in Figure 2C (asterisk; i.e., the small dSpikes identified by the most stringent criterion; see 'Materials and methods').
Given the magnitude of the improvements shown by our models, we did not have to use the most stringent settings for the thermodynamic integration method, which would obviously have increased computational demands even more.
