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Thus, our most stringent dataset contains no positive evidence of RNA editing.
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Dataset (I) represents the most stringent one, whereas dataset (IV) is the most relaxed and contain the largest number of predicted TFBSs.
The NKI dataset had the most inclusive tumor quality control criteria (> 50% tumor nuclei) and required the most aggressive corrections (30% adjustment), while the Naderi et al. dataset with median 60% tumor nuclei required 20% correction and the Wang et al. dataset had the most stringent quality controls (> 70% tumor nuclei) and required the least adjustment (10%).
This cut-off was the most stringent parameter setting applicable and ensures that the datasets show no substantial sequence similarity.
To limit the drawing of conclusions from a dataset comprising of possible false positives, only the most stringent peaks were considered that showed a FDR ≤0.05.
The most stringent uniqueness threshold of zero percent would be appropriate for datasets that are released to the public.
Quite the contrary, the success rate derived by the jackknife test on such kind of stringent dataset would actually be under-estimated in comparison with the success rates of practical applications in most cases, as will be seen later.
"Best" efforts is the most stringent standard.
"We abide by the most stringent rules," he said.
The changes are among the most stringent in the country.
Media companies have taken the most stringent steps so far.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com